Which cell normally develops into a macrophage once it infiltrates tissue?

Which cell normally develops into a macrophage once it infiltrates tissue?

• A. Monocyte
• B. Mast Cell
• C. Lymphocyte
• D. Basophil

Answer: (A)

Monocytes circulating in the bloodstream migrate into tissues during inflammation and differentiate into macrophages. This transition explains why this cell is the normal precursor for tissue macrophages, which then perform phagocytosis, antigen presentation, and cytokine production. Other listed cells have different destinies: mast cells mature in tissues and are involved in allergic responses; lymphocytes become T or B cells; basophils are granulocytes involved in hypersensitivity.

Monocytes circulating in the bloodstream migrate into tissues during inflammation and differentiate into macrophages. This transition explains why this cell is the normal precursor for tissue macrophages, which then perform phagocytosis, antigen presentation, and cytokine production. Other listed cells have different destinies: mast cells mature in tissues and are involved in allergic responses; lymphocytes become T or B cells; basophils are granulocytes involved in hypersensitivity.